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Gastrointestinal conditions may show earlier improvement, often becoming apparent during the first month of treatment

Tetramethylpyrazine (TMP), an active component in both CHF and the medicinal herbs Ligusticum wallichii (Chuanxiong) , has the potential to prevent AKI via a variety of processes, including ameliorating oxidative stress damage, suppressing inflammatory responses, deterring apoptotic cell death of intrinsic renal cells, and modulating autophagy (Gong, 2018

Both peptides have the potential to contribute to the creation of a more permissive milieu through attenuation of pro-inflammatory signaling

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