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These findings demonstrate that targeted aza-substitution yields a protease-stable, biologically active GLP-1RA with metabolic benefits, establishing azapeptides as a promising scaffold for next-generation incretin-based therapies in diabetes and obesity

3.2.3 Inflammatory mediator release Astrocytes, when stimulated by epileptiform activity (e.g., repeated depolarization or IL-1), secrete various inflammatory mediators such as IL-6, TNF-, and CCL2

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