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Metabolic Transformation Study in vivo In this study, a simple and sensitive qualitative method based on liquid chromatography combined with Q-Exactive-Orbitrap tandem mass spectrometry in both positive and negative ion modes (detailed parameters of detection can be seen in above methods) was established for the determination of ASD and metabolites in rat samples obtained in excretion study, including the fecal homogenate, urine and bile

Endocrinology 149:32943305 Reddy GR, Pushpanathan MJ, Ransom RF, Holzman LB, Brosius FC 3rd, Diakonova M, Mathieson P, Saleem MA, List EO, Kopchick JJ, Frank SJ, Menon RK (2007) Identification of the glomerular podocyte as a target for growth hormone action