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These combined effects explain why tirzepatide produces substantial weight lossup to approximately 21% of body weight in adults without diabetes at the 15 mg dose in clinical trials, with somewhat lower averages in people with type 2 diabetesalongside improvements in hemoglobin A1c levels

Storage: store in a closed container at room temperature

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This functional diversity is further exemplified by alternative splicing of SHMT2 gene, which generates two distinct isoforms: the canonical mitochondrial SHMT2 and a shorter variant, SHMT2, lacking the mitochondrial targeting sequence due to exon 1 exclusion