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IGF-I/IGF-IR signaling in osteoclasts Studies of global IGF-I KO mice showed fewer (76% of WT control) and smaller osteoclasts with fewer nuclei in the bone (65), indicating impaired osteoclastogenesis and bone resorption (Figure 2)

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Faktoren fr oxidativen Stress sind zudem psychische Belastungen und Stress, krperliche berlastung (Sport, Arbeit), Verletzungen, Operationen, Diabetes, Fettstoffwechselstrungen, chronisch-entzndliche Erkrankungen sowie Leber-, Nieren- und Darmbeschwerden

These findings have implications for aging research where both sleep quality and GH production naturally decline, as well as for recovery optimization studies in athletic and rehabilitation contexts