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WaterColor and WaterOrientation VIDA extensions were applied to the results of SZMAP calculations to visualize the regions that favor polar and non-polar substituents

As women enter menopause, estrogen levels drop and bones become more fragile, increasing the risk of fractures

Acknowledgments We would like to thank all staff from the Clinical Medicine Research Center, Affiliated Hospital of Inner Mongolia Medical University for their professional help

There is evidently a need for double-blind, placebo-controlled studies to better determine the efficacy and safety of Se supplementation in pregnancy at high risk for complications, and for measurement of Se levels or of selenoprotein P, the most reliable parameter of Se status, particularly in selenopenic regions