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Clinical studies, including the STEP 1 extension trial, have demonstrated that patients who discontinue GLP-1 receptor agonists often regain a significant portion of lost weightsometimes two-thirds or morewithin one year of stopping treatment

According to the 2024 multi-society guidance from the ASA and other professional organizations, most patients can continue GLP-1 receptor agonists before elective procedures with appropriate risk assessment and mitigation strategies

This matters because even a one-unit error at high concentrations translates to meaningful dose differences

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