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High-frequency (1018 kHz) hearing thresholds: reliability, and effects of age and occupational noise exposure
[ [PMID: 26336934] [71] Shih, A.Y
Age-related NAD+ decline impairs this critical DNA repair pathway CD38 balance: The ectoenzyme CD38 consumes NAD+ and increases with age, creating a vicious cycle of NAD+ depletion and immune dysregulation By restoring NAD+ levels, supplementation recalibrates multiple aging pathways simultaneously: improved DNA repair, enhanced mitochondrial biogenesis, restored epigenetic regulation, activated autophagy, and improved nutrient sensing
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