long acting glp 1 ra Comparison of short-acting versus long-acting GLP-1 RAs [Meier et al GLP-1 Genetics: How Genes Affect

Because tirzepatide activates two receptors (GLP-1 and GIP) while semaglutide activates one (GLP-1 only), the shape of this dose-response relationship may differ between the medications

doi: 10.1046/j.1471-4159.2000.0741968.x

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Within a year of stopping their original medication: 27% switched to another obesity medication 20% restarted their original drug 14% continued treatment through lifestyle interventions, such as visits with dietitians or exercise specialists fewer than 1% underwent bariatric surgery