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Further, a key glutathione-synthesizing enzyme, glutathione cysteine ligase modifier (GCLM), is decreased under oxidative stress.95 GCL dysregulation and deficit glutathione inhibit the detoxification of oxidative stress that results from dopamine metabolism and consequently lead to neural injury, especially in dopamine neuron-rich regions.9697 Glutathione is reduced in the prefrontal cortex and striatum,949899100 which are closely associated with the psychopathology of schizophrenia

Cai J, Wang F, Shi SL

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High blood pressure Stroke or cerebrovascular accident Arterial thromboembolic events Allergic reactions (rash, itching, breathing difficulty) Fatigue or joint pain Patients with a history of stroke, heart disease, or high blood pressure should discuss these risks with their doctor prior to treatment