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2.2 Biological underpinnings of oral health and vitamin D Oral health involving the health of teeth, gums, and their surrounding tissues, reflects one's general health and well-being

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For instance, excess myocardial FAs can convert into potentially lipotoxic metabolites, such as diacylglycerol and ceramides (Serra et al., 2013), which directly affect excitation-contraction coupling and ion channel/pump integrity, and later contribute to irreversible structure alterations (Nakamura and Sadoshima, 2020), which are speculated to provide a metabolic arrhythmogenic substrate for AF (Figures 35)