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These roles are thought to be linked to its influence on signaling pathways such as those involving Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor beta (TGF-)

More notably, bilirubin's regulation of ferroptosisby alleviating iron deposition and activating the Nrf-2 pathwayenhances the cellular antioxidant defense system and reduces programmed death of DA neurons under stress conditions ( Secondly, this study proposes a forward-looking perspective: bilirubin's protective effects may extend to the developmental stage of DA neurons during embryogenesis

Vitamin C concentrates in white blood cells and supports antioxidant defenses

much of the nutrient is lost before it ever reaches the bloodstream