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HIC is a specific form of IC/BPS distinguished by the presence of Hunner lesions-areas of inflammation on the bladder lining

For example, due to the downregulation of genes for purinergic receptors (e.g., P2ry12 ) and potassium leak channels (e.g., Thik-1 ) in aged mice, the ability for microglia to sense hyperactive neurons and migrate toward them in order to facilitate rapid repolarization would be reduced, impairing their beneficial modulation (Hickman et al., 2013

Bhowmick, D., Srivastava, S., DSilva, P

The study indicates this may not be because the patients aren't producing enough glutathione, it may be because glutathione is being used at a higher rate in patients with type II diabetes