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Wagner, J

The second is the paracellular pathway, where IGF-1 LR3 can be absorbed in small amounts through the intercellular space by regulating the permeability of tight junctions

Once activated, this pathway encourages pulsatile GH release , leading to a downstream increase in Insulin-like Growth Factor 1 (IGF-1) production from the liver a key anabolic hormone responsible for muscle growth, fat metabolism, and cellular repair

Preserving physiologic release of GH even while influencing the maximum concentration of the hormone in the bloodstream is critical to ensuring enhanced effects without increased side effects