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2 Identification of ER-specific metabolites under normal conditions and in response to stress

Oxidative stress Oxidative stress is a result of elevated exposure of cells to reactive oxygen species (ROS) e.g

Surgical methods for full thickness skin grafts to induce alopecia areata in C3H/HeJ mice

In the context of extremely low levels of SAMe, Dnmt3a and Dnmt3b might demethylate 5mC via deamination to thymine, which confirmed the dynamic activity of DNMTs with methyltransferases and demethylases according to the levels of SAMe [67]