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According to the World Health Organization , obesity has almost tripled since 1975 and has been a major contributor to numerous health diseases

Non-alcoholic fatty liver disease Non-Alcoholic Fatty Liver Disease is an umbrella term encompassing a spectrum of liver conditions with varying degrees of hepatic injury and fibrosis [28]

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HIV leads to the dysregulated binding of CCL2 to its receptor, C-C motif chemokine receptor 2 (CCR2), on neurons, astrocytes, and brain microvascular endothelial cells, ultimately leading to the increased permeability of the bloodbrain barrier (BBB) [51]