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Safety & Protocols: The compound is generally well tolerated with mild transient injection-site reactions

Folate and vitamin B 12 are important for cell division and tissue growth through their involvement in pyrimidine and purine nucleotide synthesis for DNA and RNA, maintenance of genomic stability and methylation reactions (Reference Bailey, Stover and McNulty5Reference Allen, Miller and De Groot7)

It was recently shown that biallelic mutations in ADH5 and accumulation of FA can cause a particular type of IBMFS observed in individuals carrying the highly prevalent ALDH2*2 mutation (IBMFS/AMeD syndrome) 10, 14