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Emerging data are studying its relationship to muscle mass and metabolic recovery in aged subjects Studied for gut microbiota changes when combined with a reduced-calorie diet

- when there is risk of torsades de pointes, for example in patients with prolonged QT, concomitant administration of other medications that produce torsades de pointes (amiodarone, quinidine, bepridil, IV erythromycin, halofrantine, pentamidine, sparfloxacin, sultopride, vincamine, betrilio, disopyramide, sotalol, etc)

It targets and inhibits the activity of an enzyme known as NNMT, which has been linked to a slowdown in metabolism and a reduction in energy production