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Maintaining cellular NAD supports mitochondrial function, stress resilience, and metabolic flexibilitykey mechanisms linking NNMT inhibition to improved energy balance (Kannt & Pfenninger, Frontiers in Physiology )

Most people meet these needs through diet alone, but older adults, people on strict plant-based diets, and those with digestive disorders may benefit from supplements, though dosages vary based on individual needs

Mechanism Selective NNMT inhibition, proposed to preserve intracellular NAD+/SAM and reduce fat-cell lipogenesis demonstrated in mice, not humans

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