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Abbreviations cAMP Cyclic AMP EGFR Epidermal growth factor receptor ECM Extracellular matrix protein IL-1 interleukin 1 beta MIP-1 Macrophage inflammatory protein 1 alpha MMPs Matrix metalloproteinases nAChRs Nicotinic acetylcholine receptors NADPH oxidase nicotinamide adenine dinucleotide phosphate oxidase NNAA 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal) NNAL 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone NNN N-nitrosonornicotine PDAC Pancreatic ductal adenocarcinoma PDGF Platelet-derived growth factor TGF- Transforming growth factor beta Footnotes Conflicts of interest: The authors disclose no conflicts