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Undesirably high PPG levels are associated with cognitive decline: PPG [postprandial plasma glucose] excursion is associated with a decline in cognitive functioning and that a tighter control of PPG may prevent cognitive decline. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) a class of drugs that Semaglutide belongs to have been shown to to reduced glucose reabsorption and subsequent reductions in PPG. This supports the use of Semaglutide to slow or possibly prevent age-related cognitive decline by limiting PPG
Diabetologia 59 , 11121120 (2016)
Recommendations include: Gradual Transition Slowly reduce Wegovy dosage while introducing multiple doses of the new therapy
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