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After verifying the results of the previous, highly controlled studies, the researchers expanded their study population to make it more reflective of HFpEF cases in clinical practice, finding that overall, the drugs were associated with a greater than 40% reduction in heart failure hospitalization or all-cause mortality as compared with sitagliptin

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Meals are planned to begin with protein-rich foods so that adequate protein is consumed despite reduced hunger, which helps protect muscle mass during weight loss 8