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Additionally, estrogen supplementation appears to have an effect against oxidative stress in PD brains (Numakawa et al., 2011

As important immune cells, macrophages exhibit functional plasticity [8], differentiating into classically activated (M1) or alternatively activated (M2) phenotypes under specific stimuli [9, 10]

GIP has been shown to decrease food intake & increase energy expenditure therefore resulting in weight reductions & when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose, & lipides

But concentrations are seven to 10 times higher in liver cells than anywhere else