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The decision to combine these medications should never be made without medical supervision, and patients should not initiate orlistat (even the over-the-counter formulation) while taking tirzepatide without discussing it with their healthcare provider

Following up with your healthcare provider for regular monitoring and discussing concerns is essential

Some weeks might bring noticeable changes on the scale, while others may reveal progress in how your clothes fit, improved energy levels, or better blood pressure readings

This article will explore the research on semaglutide and fatigue, explain why it happens, and provide practical strategies to help you manage low energy while still benefiting from the medication