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For HCV gt1b isolates with available complete replicase sequences 21,30,31 , phylogenetic analysis showed FCH-associated variants at various positions across the tree, indicating that probably any isolate might be able to evolve into a high replicator variant by acquiring ReED mutations (Fig

Results: Individuals who developed albuminuria were more likely to be men, had a higher HbA 1c , systolic BP and were more likely prescribed a RAAS inhibitor at baseline

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