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Early human trials in people with obesity found that daily AOD9604 was well tolerated and had a safety profile similar to placebo, with no major effects on glucose metabolism or IGF1, though weightloss results were modest and inconsistent

These changes are associated with increased systemic inflammation markers, and some investigations have made correlations of microbial imbalance with faster disease progression (Obrenovich et al., 2020)

Reduced susceptibility to apoptosis is a crucial mechanism of acquired resistance, as evidenced by scholarly research (Solier et al., 2023)