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Research from the STEP trials shows that nausea affects 40% to 44% of participants, while constipation, diarrhea, and vomiting are also common

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HO-1 contributes to luteolin-triggered ferroptosis in clear cell renal cell carcinoma via increasing the labile iron pool and promoting lipid peroxidation

This gradual titration allows the body to adapt to the medication and reduces the likelihood of nausea, vomiting, and diarrhoeathe most commonly reported adverse effects