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This document consolidates existing evidence to this effect, and adds insights from practicing clinicians to guide about use of NAC in clinical practice

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[DOI] [PMC free article] [PubMed] [Google Scholar] Bottino F., Lucignani M., Napolitano A., Dellepiane F., Visconti E., Rossi Espagnet M.C., Pasquini L

We hypothesize that PPARa attenuates TSCI-induced neuronal ferroptosis by transcriptionally activating the FSP1-CoQ10-NAD(P)H axis, thereby mitigating lipid peroxidation and preserving neuronal function