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Phentermine elevates heart rate and blood pressure by stimulating norepinephrine release, while semaglutide can independently affect cardiovascular functionparticularly in patients with pre-existing hypertension or cardiac risk factors

2023 [cited 2023 Apr 24]

The SUSTAIN trial program, which evaluated semaglutide for type 2 diabetes across multiple Phase 3 studies enrolling thousands of participants, did not identify urinary tract infections as a statistically significant adverse event compared to placebo

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