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Ghrelin has an inverse relationship with body mass index and it is significantly lower in obese individuals compared with lean ones.81 Ghrelin is the hormone of hunger, and this picture would fit with the notion of homeostatic control of body weight

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The acetyl-CoA can enter the tricarboxylic acid (TCA) cycle for production of reducing equivalents for oxidative phosphorylation resulting in ATP production, or may enter the ketone body synthesis pathway in the liver