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On the more skeptical side, tolerability at the highest weekly dose (1.2mg) may be less favorable and finding an optimized efficacy/safety profile as Metsera is doing could enhance the drugs competitive positioning

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Potential indications include: Chronic weight management Type 2 diabetes Metabolic dysfunction-associated steatohepatitis (MASH / NASH) Other metabolic diseases Yao Pharma will continue its ongoing Phase 1 trial in Australia , after which Pfizer takes full control of global development and commercialization

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