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Consistent with this, exendin-4 increases survival and levels of tyrosine hydroxylase, the key enzyme for dopamine production, in primary neuronal cultures treated with the dopaminergic toxin 6-hydroxydopamine (6-OHDA) [843]

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However, our local pharmacies report intermittent supplies from distributors, so prescribers are urged to ensure consistent local supplies prior to full-scale implementation of this new guidance, in order to avoid jeopardising supplies to those already receiving Rybelsus treatment

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