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GLP-1 receptors are widely distributed throughout the body and have multiple biological effects: suppressing appetite, reducing neuroinflammation, regulating blood lipid metabolism and reducing fat deposition ( Lymphedema is a fundamentally immunologic disease characterized by lymph stasis inducing CD4+ T cell activation and T-helper 2 cell differentiation ( in vitro study by Lieberman et al, demonstrated that GLP-1 RA inhibits chemokine-related migration of human CD4+ lymphocytes ( It is important to note that the Semaglutide Treatment Effect in People with Obesity (STEP1) clinical trial excluded individuals with a history of malignant neoplasms within five years of screening and therefore, there are no data from clinical trials regarding the weight loss effects, and potential risks or benefits of semaglutide in individuals with breast cancer
CRediT authorship contribution statement All authors contributed to the preparation and critical modification of the manuscript and approved the submitted version
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