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An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin

Further supporting this, luciferase assays revealed that while HRD1 does not affect BMAL1 promoter activity, it significantly represses PER1 promoter activity in the presence of BMAL1 and CLOCK, suggesting that HRD1 regulates the expression of PER1 and DBP indirectly by reducing BMAL1 protein levels (Guo et al., 2020)