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MLN3897 Plus Methotrexate in Patients With Rheumatoid Arthritis: Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of an Oral CCR1 Antagonist in a Phase IIa, Double-Blind, Placebo-Controlled, Randomized, Proof-of-Concept Study

Common side effects include shakiness, headache, and increased heart rate, which often diminish with continued use

Collectively, these studies support the versatile antibacterial potential of CQDs through various mechanisms, however, most evidence remains derived from in vitro systems, with limited in vivo validation and safety profiling, highlighting the need for further evaluation prior to clinical translation