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It is often the first-line drug therapy for the condition, and helps to lower blood glucose levels by: making the bodys cells more sensitive to insulin slowing the release of glucose stored in the liver slowing the absorption of glucose from food in the gut However, metformin has a number of Common side effects of metformin can include: digestive problems, such as diarrhea, vomiting, and flatulence abdominal discomfort headaches lack of energy Taking the medication with food may help reduce the risk of digestive problems

In addition to the reported GI blood loss that can play a role in iron deficiency seen in endurance athletes, such as marathon and distance runners, I think that excess sweating may also play a role in why iron deficiency is so common in these types of athletes

These devices allow for localized drug release, minimizing systemic exposure and side effects while maximizing therapeutic efficacy (243)

Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athlete tennis players