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Hazen, M.D., Ph.D., The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis

The core protein, however, remains within the cytoplasm after cleavage from E1, E1 and E2 are embedded in the ER membrane, and their extracellular domains are glycosylated

Twice-daily administration would increase total daily receptor activation without providing additional time for structural consolidation, potentially accelerating receptor desensitization without proportional benefit