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Emotional reactions Stress, anxiety, and depression can manifest as physical symptoms, one of which is a lump in the throat

The unabsorbed residues deposit in the intestine, which forces the intestinal mucosa to fill with large quantities of black or brown pigment.31 The use of anthraquinone laxatives can result in the displacement of electrolytes and water loss in the intestinal tract and sequentially lead to the deposition of protein products after using such laxatives for a long period

2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin

Signal Transduction Targeted Ther (2021) 6(1):291