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Consistent with its planned expansion into larger/large molecule bioanalysis, a number of LC-MS/MS assays for therapeutic peptides have been developed in recent years that are the focus of this discussion piece: Bioanalytical Method Development: Semaglutide Semaglutide is a glucagon-like peptide-1 (GLP-1) analog that increases insulin secretion, thereby increasing sugar metabolism, and is indicated in the treatment of type-2 diabetes and long-term weight management