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The Role of Co-Factors For glutathione to work efficiently, it needs certain "helpers" or co-factors

Moreover, while ONOO - production seems to be independent of inducible nitric oxide synthase (iNOS) (Saito et al., 2010), neuronal NOS (nNOS), which is present in hepatocytes, may play a role as nNOS inhibition or deficiency has been shown to protect against APAP-mediated liver damage ( - in APAP hepatotoxicity, manganese superoxide dismutase (SOD2) deficient mice exhibit increased liver injury accompanied by enhanced ONOO - and protein carbonylation following APAP challenge (Ramachandran et al., 2011)

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