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This review proposes a paradigm shift toward "Hardware Restoration." We begin by rejecting "normal" standard imaging in favor of objective functional diagnostics like EYEBOX tracking, Quantitative EEG (BrainView) , and metabolic imaging (SPECT/PET)

So what does the anaesthetic team need to know

Expert Consensus: American College of Physicians: GLP-1 receptor agonists should be considered for patients with obesity who have not achieved weight loss goals with lifestyle modifications. Endocrine Society: Semaglutide and tirzepatide represent significant advances in obesity pharmacotherapy and should be considered first-line options. Obesity Medicine Association: The dramatic efficacy of GLP-1 and dual agonist medications has fundamentally changed the treatment landscape for obesity. Real-World Effectiveness: Studies of patients using these medications outside clinical trials show: GLP-1s: Similar to clinical trial results (confirming real-world effectiveness) Older medications: Often less effective in real-world than trials (adherence issues) Patient satisfaction: Highest with GLP-1s Bottom Line: Which Works Best

A key component of the sterility assurance quality control, quality assurance and validation process is the method of sterility testing