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The primary objective of the study was to demonstrate that orforglipron is superior to placebo in mean body weight change from baseline at 72 weeks.

8 BaltrusD

FIGURE 3 Nuclear factor-erythroid-derived 2-like 2 (NFE2L2, also named Nrf2) is a transcription factor which plays a crucial role in resistance to oxidative stress (Xu et al., 2021)