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Side Effects of Spironolactone Common Side Effects Dizziness and headache Gastrointestinal upset such as nausea or diarrhea Hyperkalemia leading to muscle weakness or palpitations Hormonal effects including gynecomastia and menstrual irregularities Serious Adverse Effects Severe hyperkalemia with potential for life-threatening arrhythmias Renal dysfunction and elevated creatinine levels Endocrine-related side effects such as impotence or breast tenderness Drug Interactions Interaction with ACE inhibitors and ARBs Combined use significantly increases the risk of hyperkalemia and requires close monitoring

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