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In ALS, cytosolic TDP-43 translocated into mitochondria via TOM20, triggering ROS production and mitochondrial DNA (mtDNA) release through the mitochondrial permeability transition pore (mPTP)

Cependant, des doses leves peuvent provoquer des effets secondaires tels que des problmes gastro-intestinaux, des ractions allergiques ou des ruptions cutanes chez certaines personnes

While the liver and kidneys handle most detoxification, the skin provides a secondary route, and increased sweating can reduce overall toxin burden

Figure 2 Therefore, modulating autophagy represents a viable strategy to enhance the efficacy of MSC-based therapies for pulmonary fibrosis ( Moringa oleifera , suppresses hepatic fibrosis by inhibiting the activation of hepatic stellate cells