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Although metabolomics provides a powerful platform for identifying molecules and pathways involved in multifactorial disease such as PsA, the literature review revealed that few studies have explored the association between the metabolome and PsA pathogenesis, with various amino acids and lipids identified as potential, but not fully validated, biomarkers

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For comparisons among three or more independent groups, one-way analysis of variance (ANOVA) followed by Tukeys multiple comparisons test was applied when variances were equal, whereas Welchs ANOVA with Dunnetts T3 post-hoc test was used when variances were unequal