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Remarkably, therapy by topical replacement of TGM1 corrected skin architecture and dramatically reduced transepidermal water loss (Aufenvenne et al., 2013)

La principale differenza si riscontra nella loro struttura chimica e nelle loro funzioni biologiche

However, given that large peptides like GLP-1 interact with both the extracellular and transmembrane domains of the GLP-1R ( 32 ), and that our small molecules were unlikely to recapitulate this complex binding mode, it was unclear whether the competition binding experiments with radiolabeled GLP-1 were providing an accurate measure of affinity ( 25 )

Compensatory hyperphagia and concurrent diuretic therapy were some of the main explanations that were suggested in order to justify this finding