Actually, the unpublished data of our team indicates that acidosis can induce neural stem cell damage through excessive activated acid-sensing ion channels (ASICS), which are abundantly located on the dendritic spine of CSF-cNs
Examples of synthetic GLP-1 are Semaglutide (ozempic, wegovy) which last 1 week, Liraglutide (Victoza, Saxenda) which last 24 hours, Tirzepatide (Mounjaro, Zepbound) which last 1 week and also targets GIP, and finally Exenatide (Byetta, Bydurette) which can last hours to a day
Modern GLP-1 receptor agonists have demonstrated average weight loss of 15-20% of body weight with sustained treatment, representing a breakthrough in obesity pharmacotherapy that approaches the effectiveness of bariatric surgery
Older adults may benefit too, since its harder to absorb B12 as we get older