NICE guideline NG136 ( Hypertension in adults: diagnosis and management ) recommends the following approach to first-line treatment: ACE inhibitor or ARB for people aged under 55 who are not of Black African or AfricanCaribbean family origin Calcium channel blocker (CCB) for people aged 55 or over, or for people of Black African or AfricanCaribbean family origin at any age Thiazide-like diuretic if a CCB is not tolerated or is unsuitable (for example, due to oedema) From a hair-loss perspective: ACE inhibitors (such as ramipril or lisinopril) act on the same reninangiotensin system as losartan and have also been associated with rare cases of alopecia
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In rodent models, vildagliptin enhanced blood flow recovery and capillary density in ischemic limbs with accompanying increases in endothelial nitric-oxide synthase [119] and prevented left ventricular hypertrophy caused by continuous beta-adrenergic stimulation by isoproterenol [120]
